WORCESTER Warriors back row Cornell du Preez has been left out of the Scotland squad for the Guinness Six Nations crunch clash with England.

The 28-year-old, who was on the bench for the narrow defeat to Ireland last weekend, misses out while Edinburgh flanker Magnus Bradbury returns for the Calcutta Cup encounter at Murrayfield on Saturday (4.45pm).

Bradbury, who scored in last year's thrilling 11-try draw at Twickenham, sat out the opener in Dublin due to a thigh strain.

His recall to Gregor Townsend's team in place of club-mate Nick Haining is the only change to the XV which went down 19-12 at the Aviva Stadium.

Haining drops back to the bench, taking du Preez's place.

England have performed major surgery to the team defeated by France by making five changes.

Veteran Leicester scrum-half Ben Youngs is demoted to the bench, making way for Willi Heinz.

Loosehead prop Joe Marler is jettisoned from the 23 with Mako Vunipola starting and Ellis Genge deputising among the replacements.

Courtney Lawes has been relieved of his blindside flanker duties in a move that elevates Lewis Ludlam into the back row but Tom Curry is retained at number eight for a second match.

The second row sees George Kruis come in for Charlie Ewels, the Bath lock who has also paid the price for a below-par opening to the championship in Paris.

Jonathan Joseph's selection at outside centre is an enforced change after Manu Tuilagi was ruled out of the trip to Edinburgh by a groin strain that should see him return against Ireland two weeks later.

George Furbank endured an error-strewn Test debut at the Stade de France but he survives at full-back and is part of an unchanged back three.

Worcester back row Ted Hill has not made the match-day set-up after being involved with the training squad.

England: Furbank (Northampton Saints); May (Leicester Tigers), Joseph (Bath Rugby), Farrell (Saracens, capt), Daly (Saracens); Ford (Leicester Tigers), Heinz (Gloucester Rugby); Vunipola (Saracens), George (Saracens), Sinckler (Harlequins), Itoje (Saracens), Kruis (Saracens), Ludlam (Northampton Saints), Underhill (Bath Rugby), Curry (Sale Sharks). Replacements: Dunn (Bath Rugby), Genge (Leicester Tigers), Stuart (Bath Rugby), Launchbury (Wasps), Lawes (Northampton Saints), Earl (Saracens), Youngs (Leicester Tigers), Devoto (Exeter Chiefs).

Scotland: Hogg (Exeter, capt); Maitland (Saracens), Jones (Glasgow), Johnson (Glasgow),Kinghorn (Edinburgh); Hastings (Glasgow), Price (Glasgow); Sutherland (Edinburgh), Brown (Glasgow), Fagerson (Glasgow), Cummings (Glasgow), Gray (Glasgow), Ritchie (Edinburgh), Watson (Edinburgh), Bradbury (Edinburgh. Replacements: McInally (Edinburgh), Dell (London Irish), Berghan (Edinburgh), Toolis (Edinburgh), Haining (Edinburgh), Horne (Glasgow), Hutchinson (Northampton), Harris (Gloucester).